What is the use of PCA in ethnicity correction

I know population stratification is the issue in GWAS, but I could not understand the basis for using Principal component analysis for population studies in terms of allele sharing proportion. Can someone please clarify me ?

pca

• 2,161 views • link

updated 7.3 years ago by Biostar

• written 10.4 years ago by MAPK

Can you elaborate on this specific point:

in terms of allele sharing proportion

• 0 views • link

written 7.3 years ago by Kevin Blighe

0 answers

No answers yet.

More posts like this

Does Plink under perform ? ( GWAS )
written 2.0 years ago by basnet.soren •

Hello, I am performing GWAS in a subset of population which consists of about 250 individual cases. I am running GWAS and association studies on …
Number of PCA for GWAS
written 3.8 years ago by waqaskhokhar999

I have performed the population structure analysis of around 400 accessions. The structure software identified two sub-populations. Now I am interested to perform GWAS. The …
Can PCs from PCA of "Chip Genotypes" be used for post-imputation GWAS? [to adjust for population …
written 4.2 years ago by Pine •

Hi all, I have both "chip" and "post-imputation" genotype data. I want to use principal components (PCs) of population genotypes to adjust for population stratification …
How to check the allele strand of variants?
written 7.4 years ago by seta

Hi all, I have a list of variants obtained from various GWAS studies, it is important for me that all variant alleles (alternate allele) located …
How to check the allele strand of variants?
written 7.4 years ago by seta

Hi all, I have a list of variants obtained from various GWAS studies, it is important for me that all variant alleles (alternate allele) located …
PCA: summarize results from principal components analysis and look for population heterogeneity
written 8.1 years ago by F_cm_C •

Hi! I am conducting a GWAS. I used plink 1.9 (--pca) to obtain first 10 population principal components which I entered in the regression model …
principal component plot interpretation
written 9.4 years ago by ED •

Hello I'm reading a paper but I have some difficulties with interpreting a principal component plot. I'm not familiar with principal component analysis so I …
Methods to correct for population stratification
written 10.2 years ago by MAPK

I have been working on GWAS like projects and trying to correct for population stratification in my data. I have performed principal component analysis to …
Interpretation of Eigenstrat results
written 10.7 years ago by kelly.wang135

Hi, I'm trying to use principal component scores to adjust for population in GWAS. I'm a beginner of principal component analysis using Eigenstrat and have …
Dealing With Population Stratification In Gwas
written 14.3 years ago by Nasir

<p>My question is a bit 'general' and I would be very grateful for any advice. I have data from a GWAS on unrelated Western European …