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Alternatives to Broad's DAPPLE tool?
Entering edit mode
4.4 years ago
sic • 0
United States

Hi everyone

I have a set of coding variants, on which I want to run some protein protein interaction tools. I've used a couple of resources so far (String, CPDB), and I really want to use Broad's (online) DAPPLE tool. Unfortunately it's been down for some time now, and I can't get a hold of the tool's developers, nor can I find any sources to download so I can run it locally.

My questions - is there anyone here that has used this tool? Could anyone recommend a similar tool, or does anyone have source I could install/run locally?

For reference I've attached a link to a figure generated by DAPPLE, from Neale et al's 2012 article "Patterns and rates of exonic de novo mutations in autism spectrum disorders":

Thank you!

Entering edit mode

Hi sic.

What type of analysis exactly you want to do?

As far as I know, DAPPLE gets a list of genes or SNPs and creates the PPI network of the proteins involved with these sets. I'd recommend you to try Cytoscape apps.


Entering edit mode
3.7 years ago

Hi Sic,

You could try GeneNet Toolbox for MATLAB. I am the author of this toolbox, and it is available at:

Hope this helps.



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