This is a test version of Biostars. For the public version, visit https://www.biostars.org.
How much of human genome transcribe? How much of transcriptome are non-coding RNAs?

Hi all,

I'm looking to understand, how many percent of human genome are transcribe? How much of transcriptome are protein coding an much are non-coding RNAs ?

next-gen genomics rna-seq
• 11,174 views • link
updated by Ram Ram • written by jack jack

Exact number can not be given as this has cell type specificity. For example, there are much more non coding RNA and endogenous retroviral elements are expressed during development and in cancers which occupy much proportion of genome in comparison to that of normal differentiated cell types.

• 0 views • link
updated by Ram Ram • written by Manvendra Singh Manvendra Singh

1 answer

N.B. This is edited from the original, which was a post-closing comment. Due to that, some replies may not seem directly connected.

Have a look at this paper for some useful numbers.

In short, 5-10% of the human genome is transcribed and ~2% is protein coding.

• 0 views • link
updated by Ram Ram • written by Devon Ryan Devon Ryan

I disagree a bit here. I think that we all need to have a good sense of the sizes and magnitudes because they help us choose the right approaches, provide sanity checks and other estimates. It may not be computing related but it affects computing greatly.

• 0 views • link
updated by Ram Ram • written by Istvan Albert Istvan Albert

Fair enough.

• 0 views • link
updated by Ram Ram • written by Devon Ryan Devon Ryan

I am going to move the comment to an answer because the link in there does actually provide all the answers.

• 0 views • link
updated by Ram Ram • written by Istvan Albert Istvan Albert

OK, I've reformatted it more as an answer and left a note mentioning why there are seeming non sequitor comments.

• 0 views • link
updated by Ram Ram • written by Devon Ryan Devon Ryan

Istvan, you are completely right

• 0 views • link
updated by Ram Ram • written by jack jack

Log in to answer this question.

More posts like this