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How to visualize a large number of GO terms in directed acyclic graphs

Hi,

I have a list of about 500 GO terms that I want to visualize in directed acyclic graphs so as to figure out their relationships.

Is there a tool that would let me input my list of GO terms and gives me directed acyclic graphs of the GO terms as output?

I tried EBI QuickGO tool, but it does not work with a lot of GO terms.

I am open to alternative strategies/suggestions.

Let me know if you have any questions.

Thanks.

go-terms acyclic-graphs gene-ontology
• 5,332 views • link
updated by Ram Ram • written by oussumenten • oussumenten

2 answers

I wrote a XSLT stylesheet transforming GO to XML+GEXF . See https://github.com/lindenb/xslt-sandbox/blob/master/stylesheets/bio/go/go2gexf.xsl

The resulting graph can then be visualized using http://gephi.org

$ curl "http://archive.geneontology.org/latest-termdb/go_daily-termdb.rdf-xml.gz" |\
gunzip -c |\
xsltproc --novalid go2gexf.xsl -

output:


<gexf xmlns="&lt;a href=" http:="" www.gexf.net="" 1.2draft"="" rel="nofollow">http://www.gexf.net/1.2draft" xmlns:g="http://www.gexf.net/1.2draft" xmlns:go="http://w
ww.geneontology.org/dtds/go.dtd#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:viz=
"http://www.gexf.net/1.1draft/viz" version="1.2">
  <meta>
    <creator>Pierre Lindenbaum</creator>
    <description>Gene Ontology</description>
  </meta>
  <attributes class="node">
    <attribute id="0" title="definition" type="string"/>
  </attributes>
  <graph mode="static" defaultedgetype="directed">
    <nodes>
      <node id="GO:0000001" label="mitochondrion inheritance">
        <attvalues>
          <attvalue for="0" value="The distribution of mitochondria, including the mitochondrial gen
ome, into daughter cells after mitosis or meiosis, mediated by interactions between mitochondria and
 the cytoskeleton."/>
        </attvalues>
      </node>
      <node id="GO:0000002" label="mitochondrial genome maintenance">

(...)
• 0 views • link
updated by Ram Ram • written by Pierre Lindenbaum Pierre Lindenbaum

Try out the RamiGO package in Bioconductor

It allows you to produce Amigo Trees which shows the relationship between GO terms

• 0 views • link
updated by Ram Ram • written by andrew.j.skelton73 andrew.j.skelton73

I have looked at RamiGO but it does not support a large number of GO terms. Thanks though.

• 0 views • link
written by oussumenten • oussumenten

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