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gene-expression data from RNA-seq

I downloaded a dataset for alzheimer-gene expression RNA-seq data from NCBI: accession number:GSE281454 why we have the column FC (SHSY5Y_vs_diffSHSY5Y_FC) contains numbers like -500 or +100. Is it logical for FC(as I know it shoud be a postive small number)enter image description here

gene-expression rna-seq
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updated by i.sudbery i.sudbery • written by yana • yana

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It refers to log2 fold change

Data processing The sequence data were mapped to the human reference genome hg19 with STAR-2.7.10a FeatureCounts (subread-2.0.3) was used to quantify gene expression (parameters applied: "“-s 2 –p –Q 10") Differential expression analysis was performed using edgeR Assembly: human reference genome hg19 Supplementary files format and content: excel file including raw counts, log2 fold change, p-values and FDR enter image description here

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updated by i.sudbery i.sudbery • written by kaslana • kaslana

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