When i tried to learn any new bioinformatics assay, then my seniors suggested me to replicate the relevant research paper. but to do so i got many problems and hurdles like first of all reading and understanding the context of paper, then the used methods, data visualizations and last but most tough part statistical evaluation of analysis and results. I request for efficient way or methods to do this painful work.No doubt persistency and hard work is necessary but i need suggestions for smart work.