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I don't really understand what fold mean means

What 198-fold mean means in the following sentence:

Typically, only a small fraction of a genome has 'low' relative coverage. For example, 198-fold mean coverage of the human genome by Illumina HiSeq 2000 version 2 chemistry only left 0.23% of bases undercovered by a factor of 10 or more (data set A2). At first glance, this portion of the genome appears minuscule, but if the data were unbiased, we would expect no bases to have such a low level of coverage (more than 12 standard deviations less than the mean)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053816/

coverage
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updated by Ram Ram • written by ManuelDB ManuelDB

1 answer

it's 198-fold mean coverage. Not clear from that exerpt what it's comparing it to, but the mean coverage in one sample is 198-fold higher than a different sample.

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written by Trivas • Trivas

From the linked paper

stat

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written by GenoMax GenoMax

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