thank you!
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vcf to bcf conversion
I want to convert a .vcf.gz file into .bcf (compressed) form;
I tried the following command:
bcftools view file.vcf.gz -Ob -o file.bcf
however, when I check the converted .bcf file, I got the header showing:
##fileformat=VCFv4.2
shouldn't the fileformat be BCF?
Thank you.
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solarchan7 •
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solarchan7 •
1 answer
File format specification is Variant Call Format (VCF).
BCF is a binary representation of VCF files (section 6 from format spec doc above) :
BCF2 is a binary, compressed equivalent of VCF that can be indexed with tabix and can be efficiently decoded from disk or streams.
and
The “text” field contains the standard VCF header lines in text format, from ##fileformat=VCFv4.3 to #CHROM ... inclusive, terminated by a NUL character.
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