Hello everyone!

I am studying Breast Cancer Bone Metastasis and cell death pathways.

Some gene products will induce death at different expression thresholds. For instance, one gene might encode a microRNA that will induce cell death at a slightly higher expression than basal, but the other gene might encode a protein that causes death, but it requires higher protein expression In an experimental setting I want to measure the gene expression in a cell induced by a condition (e.g. a drug), but you need to compare it to the same cell without the condition (that’s the basal state). But since I cannot control for each gene in the array, you need to find a consensus. I don’t know what the consensus is, but it must be in the literature.

Could you recommend me some articles on this theme?

Thanks in advance!