calculating the allele frequency of a gene deletion and duplication
Lets say I have copy number data for a gene for 9106 people
Copy Number 2 8260 Copy Number 1 603 Copy Number 3 226 Copy Number 0 17
I am trying to figure out the allele frequency of the deletion and duplication.
I am not really sure how to proceed other than there are 9106 x 2 = 18,212 haplotypes.
my best guess is that the:
deletion is ((2 * 17) + 603) / 18,212) = .035 duplication is 226 / 18,212 = .012
Is that right or off the mark?
• 1,021 views
•
link
0 answers
No answers yet.
Log in to answer this question.
I do think so. ChrX and chrY are of course different.