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How annotation files are generated?

Hello! I have a bed file of some genomic regions and i am trying to annotate these regions using a GTF file. Everything works fine but my question is how these GTF files get their information from. Is it from experimental findings , is it from algorithms used to predict functional regions of the genome, is it both or is it something else? Thanks in advance!

gtf

1 answer

Depending tools it can be both or one or the other.

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