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Specificity in CMap/Clue.io?

Hi,

I have yet another question.

What is “specificity” in CMap? It is a value calculated for each drug in my output but I don’t understand what it means or what its range is or how to interpret it.

I have searched Clue Connectopedia and the original paper published but have yet to understand what is being calculated with “specificity”.

As a side question, I also don’t understand why a specific cell line is outputted for some drugs but not others.

cmap map connectivity

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