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Protein Descriptors

Are there any Python or R-based packages to determine Protein Descriptors (Sequence-based or structure-based)? I have explored some packages in the case of ligands e.g. Mordred, RDKit, etc. I'm new to Drug Discovery/Drug Repurposing any guidance would be beneficial and much appreciated. Thank you!

biopython discovery drug chemoinformatics bioconductor repurposing

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