How to convert Uniprot IDs to Ensemble Gene IDs
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see https://www.uniprot.org/help/api
Just to add to Pierre's answer, you can also do this with the xrefs endpoint in the Ensembl REST API:
Documentation: http://rest.ensembl.org/documentation/info/xref_external
E.g: http://rest.ensembl.org/xrefs/symbol/homo_sapiens/P63151?content-type=application/json
What framework are you referring to?
If you want to use UniProt's ID mapping tool: https://www.uniprot.org/id-mapping