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Downstream Analysis of snvs

Dear all, I have hundreds of vcf files (with SNV, indels) from tumor-normal samples. I am confused about how to perform downstream analysis. Is there any typical workflow or any r /python package?

I am lost! Can somebody point me in a direction.!

Thanks

snv sequencing exome

What hypothesis / question are you trying to answer?

we are trying to look at different snv's, and indels that could cause sarcoma.

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