What are the biggest sets of individual-level sequence-based variant data?
I'm not looking gnomAD or other population-level aggregations, but studies in dbGaP or elsewhere that have large numbers of individuals - can be human, model species, plants, etc. Should be exome or whole genome sequencing. Please list the number of subjects.
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Jeremy Leipzig
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There are quite a few. For example:
- ~10k: The Hartwig Medical Foundation
(https://www.hartwigmedicalfoundation.nl/) is getting close to 10k deeply sequenced
WGS tumour/normal pairs.
- ~100k: The 100,000 Genomes Project (https://www.genomicsengland.co.uk/initiatives/100000-genomes-project) has 100k samples and Genomics England continues to sequence.
- ~1M: All of Us (https://allofus.nih.gov/) is ongoing and aims to sequence 1M people.
PCGC phs000571.v6.p2: 9517 exomes
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