Bedgraph And Bigwig Files From Multiple Bams
Is it possible to combine multiple BAM files to create a consensus Bedgraph file?
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Biostar
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andrew.j.skelton73
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andrew.j.skelton73
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If you have separate bedGraph files, you could convert to bigWig and then use the bigWigMerge utility from UCSC.
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what's the 'value' in the bedgraph ? the depth ?
Depends on the nature of the data that you're getting from the bedGraph files. In general I would suspect that'd work, but I'm sure there are edge cases where it wouldn't (e.g. when using bedGraph to represent present/absent features, since calling those might be affected by merging the BAM files).