Cancer-cell-line-specific essential genes
Hi all!
Is there a cancer-type-specific database of essential genes? Specifically, I am looking for genes whose deletion would lead to loss of cancer cell lines (or loss of their growth ,....) in Glioblastoma Multiforme.
Thanks indeed.
• 1,068 views
•
link
updated
by
Kevin Blighe
•
written
by
english.server
•
written
by
english.server
1 answer
Hi, you will want the DepMap CERES crispR data:
They profiled virtually all cell-lines from CCLE.
Note: a negative CERES score indicates that the gene in question is more 'essential' for that particular cell-line's viability:
"A negative CERES score indicates that a gene knockout results in a slower growth rate of a cell line, and a score lower than − 0.5 indicates a notable reduction"
sources:
Kevin
• 0 views
•
link
written
by
Kevin Blighe
Log in to answer this question.
More posts like this
-
Database for non cancer cell lines
written by ANSARAHMAD •
-
Looking for gene expression profiles of different cell lines
written by yanbinwan •
-
Known CRISPR KO effects on gene expression
written by j.gleixner •
-
Searching for a specific cell type in TCGA
written by jabbari.parnian •
-
Drug target in specific cancer database
written by kanwarjag
-
Perturbation Cancer cell line data
written by jmannhei •
-
Essential genes from normal human cell lines
written by rheery •
-
Transformed cancer cell-lines RNA-seq database
written by ever_wudi •
-
Is it possible to get seq data for cancers via database?
written by gooshiroy •
-
Looking for cancer sequencing data.
written by reza.haffari •
