statistic test
Hello, I am naive to the statistics. for example, MACS2 detects peaks using Poisson distribution, but why does it can output p value? Another example ia RNAseq, some algorithms use NB distribution to model gene expression, and then use Wald test perform differential analysis. Why not directly using t test or other statistic test?
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The distribution type is meant to capture the expected characteristics of that data.
A p-value reflects the likelihood of the null hypothesis being true for the chosen distribution.
Think of a test as a formula that accounts for various features of the data.
If you google the concepts you will find an extremely wide array of explanations for each.
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