Is it representative to use the minimal matched data of RNA-Seq in TCGA?
Hi all,
As far as I understood, the number of "solid tissue normal" data in TCGA is minimal, and given this, I have two questions:
- For DE analysis that we need the matched data of normal and tumor tissue, is it representative to use these minimal data? Are there any alternatives?
- What is the significance of tumor tissue RNA-Seq data without their matched normal data?
Thanks for any comment
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Zhenyu Zhang
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Zahra •
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Zahra •
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- don't use TCGA normal samples for you purpose. Many of them are perinormals in nature.
- there are tons of TCGA RNA-Seq based papers published without normals
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