Hi all,

I am trying to use the ensemble Rest API to query some variants. I used the wget example provided here:

https://rest.ensembl.org/documentation/info/vep_region_post

The query is as follows, and works perfectly:

wget -q --header='Content-type:application/json' --header='Accept:application/json' \ --post-data='{ "variants" : ["21 26960070 rs116645811 G A . . ."] }' \ 'https://rest.ensembl.org/vep/homo_sapiens/region' -O -

My issue is where to place optional parameters in this query. I am looking to add loftee to my output, which is under the parameter LoF. Any advice would be greatly appreciated.