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Protein Sequence Homology Score, Align Or Blast

Hi,

I want to get homology scores for every pair of human proteins acoording to their sequence amino acid constitution. should I blast these pairs(blast2seq) or align these pairs(localAlignment)?

blast pairwise human genome

1 answer

I'd go for global alignments since the majority of eukaryote proteins consist of the same domains in different orders..

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