This is a test version of Biostars. For the public version, visit https://www.biostars.org.
Can I Write A Research Paper Based On The Results Of Comparing Computational Predictions Of Two Proteins

I have modelled a membrane protein using Insight-2 and glide's-prime. In insight - 2 I have modelled the whole protein, whereas in glide-prime I modeeled only a particular region. can I communicate this work as a comparison of prediction by these 2 methods? or can anyone suggest how I can frame these 2 works and send for publication in journal

publication
• 2,445 views • link
updated by justinhaselbach justinhaselbach • written by Lavanya • Lavanya

See also: Do you know any outer membrane protein which do not have a beta-barrel structure?

I am not sure what the requirements are for getting papers on protein models accepted, but sometimes the best way to find out might be to actually submit a paper. Personally, I would be a bit skeptical about a model without any experimental validation. So, if you could get or find some experimental data or known structure to compare your model with that might improve things, though I heard getting crystal structure of membrane proteins is harder than other proteins. Also, why don't you make a full model from both programs. The way you are describing it now sound as if the models are not really comparable.

• 12 views • link
written by Michael Dondrup Michael Dondrup

1 answer

You MUST Publish if the following are true-

  1. Similar data-sets have been published in 'some journal'. !
  2. The study is enough IN-DEPTH.
  3. There is NOVEL information available after your study on the protein's- structure, function or similar aspects.
  4. And yes, DATA without analyses and biological significance is a "house of bricks and NOT home" !

Good to be in touch with a biologist, to be able to find out more on this as well.

Thanks,

• 4 views • link
written by justinhaselbach justinhaselbach

Log in to answer this question.

More posts like this