I have a set of 2500 uniprot IDs. Now I want to identify if the proteins in my list are actually forming a complex. I found out CURUM database of complexes: http://mips.helmholtz-muenchen.de/genre/proj/corum I am wondering if there is any tool to figure out which complexes are present in my list of proteins (something like DAVID enrichment analysis).
3 answers
+1 CORUM; If you are interested in curated subset of complexes from human proteome - you can also consult HGNC gene families list. There is a total of 17 curated complex with a total of 263 genes.
Actin related protein 2/3 complex subunits
Anaphase promoting complex subunits
Biogenesis of lysosomal organelles complex-1 subunits
Components of oligomeric golgi complex
Elongator acetyltransferase complex subunits
General transcription factor IIH complex subunits
HAUS augmin-like complex subunits
Histocompatibility complex
INO80 complex subunits
Mitochondrial respiratory chain complex assembly factors
Mitochondrial respiratory chain complex / Complex I
Mitochondrial respiratory chain complex / Complex II
Mitochondrial respiratory chain complex / Complex III
Mitochondrial respiratory chain complex / Complex IV
Mitochondrial respiratory chain complex / Complex V
THO complex subunits
Trafficking protein particle complex
Protein Complexes are also annotated in Reactome. I don't think there is a tool to do what you want, but you can download the mapping files and parse them to get the proteins associated to any complex.
Log in to answer this question.
-
Is there a site that takes a list of uniprot IDs/gene IDs as input and create radial phylogenetic t…
written by Diwan
-
Protein set enrichment with protein complexes/dimers
written by bkayser •
-
How to get non-interacting protein pairs in Human
written by lakshmi.bioinformatics •
-
Protein complex databases - how many are out there?
written by Qroid •
-
DAVID and Panther can't identify certain Uniprot Accessions
written by shpak.max •
-
Which techniques for finding protein complexes are biased towards stable complexes? Which aren't?
written by Qroid •
-
How to estimate the stability of a protein complex?
written by Qroid •
-
Getting Names Of Proteins Around A Protein In A Genome
written by Pappu
-
Taxonomic Distribution Of A Protein
written by Pappu
-
How To Interpret The Results Produced For A Functional Enrichment Analysis Via David?
written by mtyler.jason •
Did you find any solution? I am confronting the same problem
@Michi Did you find any solution? If so, it would be nice to know it.