Thanks. Do you have a link to the BioGRID complexes? Again I only see pairwise interactions.
The question is pretty straightforward: what are the published protein complex databases? We typically use CORUM but we're being encouraged to use other databases too, since CORUM is biased to very abundant complexes. A quick Google search shows a few more:
- CORUM (http://mips.helmholtz-muenchen.de/corum/)
- PCDq (https://bmcsystbiol.biomedcentral.com/articles/10.1186/1752-0509-6-S2-S7)
- 3D complex (http://www.3dcomplex.org/)
- IntAct (https://www.ebi.ac.uk/intact/complex/)
Are there others?
1 answer
Reactome and BioGRID have some protein complexes. Then there's also FuzDB. The Gene Ontology cellular component domain also has a term 'macromolecular complex' (GO:0032991). However, keep in mind that different resources have different notion of what a complex is and even for the same definition, the granularity may be different i.e. what is one complex in one database may be two or three (sub-)complexes in another.
See the BioGRID curation guide.
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STRING (http://string-db.org)
Is there an easy way to get complexes from STRING? My understanding is it's just a list of pairwise interaction.
Yes, as far as I know, STRING only has binary interactions.