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Review Papers On Short Read Mapping?
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14 months ago
Davis, California, USA

I'm teaching a course on computational genome science and next week we're focusing on short read mapping. I'm familiar with and/or have used some of the more popular mapping tools (Bowtie, BWA, Novoalign) as well as related tools for various downstream applications (Tophat/Cufflinks, Novomethyl), so I feel prepared to at least cover the basics. However, I'm curious whether there are any recent review papers that discuss the mapping problem, the various approaches used to solving it, and/or the biological questions scientists are trying to answer with these tools. Any recommendations?

mapping ngs • 2.4k views
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12 months ago
Botond Sipos ♦ 1.7k
United Kingdom

Nuno A. Fonseca, Johan Rung, Alvis Brazma and John C. Marioni (2012) Tools for mapping high-throughput sequencing data. Bioinformatics 28:3169-3177. doi:10.1093/bioinformatics/bts605

It is quite comprehensive and comes with a regularly updated online compendium of mappers.

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This is _exactly_ what I was looking for. Thanks!

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3.9 years ago
matted 7.0k
Boston, United States

They're both slightly dated and don't have the latest and greatest tools, but the motivation and descriptions are still on target. You might complement these reviews with a well-written recent paper like the GEM, bowtie2, or bwa-mem manuscripts.

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12 months ago
Leandro Lima • 920
San Francisco, CA

A solid quality-control analysis of AB SOLiD short-read sequencing data.

http://www.ncbi.nlm.nih.gov/pubmed/22877770

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