This is a test version of Biostars. For the public version, visit https://www.biostars.org.
What Are Some Good Interactive Circular Genome Browsers?

Hi all,

I am looking for a interactive genome browser for circular (viral) genomes. Something that lets users view genome features in the context of the genome while allowing for backend and user customization. I need something that is interactive not simply a program to draw a static genome representation. I am familiar with a few:

Are there others that I should be considering?

visualization genome browser

Hi Zev. You can find a description of genome here.

LOL I know what a genome is... I was asking what kind of viral genomes you work on. I studied Microviridae.

LOL for sure! The current project is for papillomavirus but my previous work includes many other viruses, especially influenza virus.

Also your link doesn't have a wiki article associated with it...

Corrected! Thanks!

5 answers

MizBee is cool, but somewhat difficult to format data for.

MizBee link

This looks cool, especially if someone want to do synteny visualization.

One browser strategy I thought was interesting was phiGenome. They had to accommodate both circular and linear genomes, so they have a circular map section but also have the linear view.

I know it's not exactly what you meant, but I thought it was a clever way to do it.

Example: http://www.phisite.org/main/index.php?nav=phages&nav_sel=pg&phage_id=10876.1%3B4491%3B2%3B3%3B1&ID=null&begin=begin&end=end&strand=both and use the Zoom slider to see the region change.

based on flash, no longer works too well for that reason

Our tool Viral Genome Organizer www.virology.ca/virology-ca-tools/vgo/ displays genomes as linear sequences, but might be useful depending on your needs.

Viral Genome Organizer (VGO) is an easy-to-use Java genome browser. It can be used to display information about a genome, including its genes, ORFs and start/stop codons. It can also be used to perform a regular expression search, a fuzzy motif search, and a masslist search. Because VGO talks to our database of genome sequences (VOCs) it can be used to compare genomes.

With this program, you can: view genes and predicted ORFs in one or a series of genomes. display start and stop codons within the sequence search for sequences within genomes using regular expressions; e.g GGATCC or TTTTT[ATCG]T using a fuzzy search pattern; e.g. GGATCC allowing one mismatch for genes with the highest AT composition use a GUI to select and extract regions of a genome display orthologs in a set of genomes by using the GUI to select a gene in another genome display a plot of nucleotide composition. search for the longest oligonucleotide shared between a series of unaligned genomes search the translated genome for matches to mass spec peptides graphically display data from other programs on top of the genome display

Hi,

You might find polar histogram: pretty and useful

enter image description here

This previous post mentions some other options too.

Hi Gjain, While those are nice uses of data visualization they are not really suited for use as genome browsers. Additionally, the are static and not interactive representations. Thanks!

Ahh yes, these are just meant for the static plots.

An open-source bioinformatics toolkit UGENE provides nice interactive circular visualization of sequences.

Important features:

  • large number of supported data formats for sequences and annotations
  • annotations editor
  • export as image or SVG

UGENE is available for Windows, Linux and MacOS.

Here is link to documentation.

Log in to answer this question.