This is a test version of Biostars. For the public version, visit https://www.biostars.org.
The Probability Of A Transcription Factor Binding To A Dna

Does anyone know the probability of a transcription factor binding to a DNA？Is this probability a constant or does it vary with the circumstances？

transcription-factor binding
• 3,655 views • link
updated by Asaf Asaf • written by kate • kate

This question is off-topic. What is the relation to bioinformatics?

• 0 views • link
written by Michael Dondrup Michael Dondrup

It doesn't really say so, but I supposed she wanted to develop a model that would include transcription factor binding.

• 0 views • link
written by Chris Evelo Chris Evelo

I think for such questions, where the relation to informatics field is not clear but only appears to be a biological question, we should require to make the connection explicit.

• 0 views • link
written by Michael Dondrup Michael Dondrup

1 answer

It varies according to Kaplan et al due to accessibility of the DNA.

• 0 views • link
written by Asaf Asaf

Thanks so much. But what does 'accessibility of the DNA' mean?

• 0 views • link
written by kate • kate

I think you should start reading that paper. But it can involve a lot of things, like chromosome folding, DNA methylation, histone based coiling, other proteins being present on the DNA etc. Actually the status of the transcription factor itself will influence the binding as well. Things like post translational modifications leading to (in)activation and complex formation.

• 0 views • link
written by Chris Evelo Chris Evelo

Log in to answer this question.

More posts like this