Thank you for your answer. I don't understand how to use AAindex database for comparing my dataset with numerical values of this database? Do you have any suggestions?
Hi,
I am trying to find the physico-chemical properties of amino acids for my data set. I would like to find the similarities and differences of my dataset with the control set. Dataset and control set are sequences in fasta format. I have already found the composition(frequency) of these sets . For example I would like to check whether my dataset is hydrophobic or hydrophilic.How can I find the physico-chemical properties of amino acids? Is there any software available to find the properties of aminoacids?
Any suggestions would be appreciated.
1 answer
Try AAindex. It's a database of indices and matrices that describe a large number of physicochemical parameters. Here's the full list of indices and here, for example, Fasman's hydrophobicity index.
EDIT
Your edited question still does not explain, precisely, what you are trying to achieve. However, it sounds as though you want to determine the properties of protein sequences based on those of the constituent amino acids. Basically, this involves writing code to (1) loop through the sequence residue by residue; (2) assign a value to each residue by storing physicochemical properties in some type of data structure (such as a hash in Perl, a dictionary in Python) and (3) calculating some kind of metric for the complete sequence (e.g. a mean, median, value across a sliding window). It's difficult to be more helpful without a clear idea of your goal.
My suggestion is that you edit your question to explain better what you are trying to do. What is your "dataset"? A set of sequences? If so, what format? What is the "control set"?
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