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how do we calculate polygenic risk score?

Hi,

Can anyone explain, how do we calculate the polygenic risk score? Can anyone give an example?

genome snp
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updated by farshad.madani • farshad.madani • written by mag • mag

https://lmgtfy.app/?q=polygenic+risk+score+calculation

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written by JC JC

2 answers

There is no standard to how these are calculated. Most seem to be derived from the beta coefficient after having fit a regression model to the data, and may thereafter be 'weighted' by some other value. If a Bayesian regression model is used, then model 'priors' (weights) can be used to weight the coefficients during model fitting.

Kevin

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written by Kevin Blighe Kevin Blighe

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