Do you always need to clump polygenic risk scores?
Hi,
I have always clumped my polygenic risk score but I recently I came across a paper that did not perform clumping on polygenic risk scores created at quite liberal thresholds. Does this not worsen the predictive accuracy and bias the effect estimates by over representing regions in high LD?
0 answers
No answers yet.
Log in to answer this question.
More posts like this
-
Forum: Help with Ideathon
written by V K •
-
Novel sparse optimisation for high accuracy cancer classification on the 33-cancer TCGA gene-expres…
written by Mark Reilly •
-
strainEST database construction, resources
written by malteherold •
-
Questions about Polygenic Risk Score (PRS) and PRSice-2
written by yiqiangz •
-
Do you always need to clump polygenic risk scores?
written by kl •
-
Plink: Understanding LD Clumping vs Pruning
written by JourneyToAbyss
-
Polygenic risk score questions - which method is best?
written by longe •
-
News: Metabarcoding: Transforming the way in which biodiversity can be surveyed
written by Physalia-courses
-
Job: Research Officer at Systems Genomics Lab, Baker Heart & Diabetes Institute, Melbourne, Austral…
written by mbrozynska
-
Forum: Isaac Asimov Accurately Predicts Woes Of Bioinformatician
written by Obi Griffith
