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Is it good to merge transcripts tpm to gene which is of different gene type?

I have gene expression data from kallisto with tpm expression. I would like to sum the tpm of transcripts that belong to the same gene and just summarize the TPMs for each gene.

But I see that same gene has a different gene_type. In that case can I sum the tpm of transcripts that belong to the gene? Do you think this can be done or not possible?

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rna-seq kallisto tpm
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updated by wensulin93 • wensulin93 • written by newbie newbie

I think gene part mutation is very normal in genome. If the similarity still remains very high, I think it is not a matter.

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written by wensulin93 • wensulin93

Are you sure this answer is relevant to the question here? What do mutations have to do with this and where is similarity assessed?

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written by WouterDeCoster WouterDeCoster

My goal is to use the genes tpm for estimating immune cell infiltration. For this I have to use Gene names and their tpm.

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written by newbie newbie

Yea, usually we use tximport or tximeta to get the gene-level values

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written by darklings darklings

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