This is a test version of Biostars. For the public version, visit https://www.biostars.org.
calculating fold change

Hi everyone i am confused with a very simple problem!! i have a list include 1074 diffrentially expression genes How to determine fold change this genes?

fold change
• 2,369 views • link
updated by Barry Digby Barry Digby • written by sh • sh

How did you get this list of differentially expressed genes?

• 0 views • link
written by ashish ashish

i performed meta-analysis in 11 microarray datasetes which was contained 307 tumor samples and 197 control samples

• 0 views • link
written by sh • sh

then your FC is the average normalized value divided by the average normalized value in controls. If you did this in R, your table should contain log2(FC), otherwise please explain the method of how this was analyzed

• 0 views • link
written by JC JC

1 answer

Take a look at this chapter, it explains very clearly how to calculate fold change

https://www.mrc-lmb.cam.ac.uk/genomes/madanm/microarray/chapter-final.pdf

• 0 views • link
written by Barry Digby Barry Digby

Log in to answer this question.

More posts like this