Hello

I am working with WGBS data and I am using MethylKit package.

There in the Descriptive statistics per sample. (a) Histogram of %methylation per cytosine for a sample, I got most of the bases have either high or low methylation. Specially 0% methylation is highest and 100% methylation is lower than that. It is a bimodal distribution. In the main paper where this package was published also showed similar trend, as they have done it on cell line. My data is on human sample.

Anyone have found any other trend? I mean where 100% methylation is highest?

Thanks
Shrinka Sen