enrichment analysis of differential methylation
Differential methylation (tumor vs normal) is now a regular analysis type. We still need to properly interpret the differential methylation. I guess we have to map the methylation profile to gene expression for downstream enrichment analysis, right?
Can anyone suggest one or two widely accepted tools that perform methylation enrichment analysis while taking proper normalization of differential methylation (normalizing number of methylation sites as wellas the contribution of each methlytation site to expression of corresponding gene)? Really appreciated.
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What exactly do you mean by this? Do you wish to combine methylation data with RNA-seq data from matched samples?