Thanks Khader for useful information.Could you please ask my extra question in future by e-mail?
1 answer
GeneMania or STRING is not ideal for inferring diseases associated with a gene list.
You can use one of the following tools/resources for diseases enriched in a disease list:
- Enrichment analysis using Disease Ontology (DO) / DO-Lite. You can Functional Disease Ontology server for enrichment analysis using DO
DAVID (Expand the Diseases tab and select options. This is mainly for genetic diseases. Default option is OMIM, also available GDA database and GDA class)
Disease subset of KEGG pathway or Reactome can be inferred using KEGG or Reactome pathway enrichment tools. See this discussion for pathway analysis)
Other options: Human Phenotype Ontology, GWAS association or any other custom disease-gene annotation/association to perform a standard enrichment analysis. Some of the key aspects of enrichment analysis is discussed here.
If you find the answer useful, you could please validate it. Please feel free to discuss your questions here as comments, so that future users can benefit from it.
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