power analysis and rare variants
Hello,
I need to assess how many individuals I need to sequence to find all variants with an allele frequency <0.001 with a power of 80%. How can I do that in R?
Thank you
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monaallouba •
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allele frequency in a control population so basically, I am trying to address the following question: At what control cohort size will I have 80% statistical power (with alpha = 0.05) to detect very low frequency variants (i.e. 0.001)?
Is this an assignment question? Again, how do you define statistical power of variant detection?