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How To Calculate The Effect Size Of Snps Vs Percent Body Fat?

I need to justify my assumptions and need to calculate the effect size of SNPs (25 in total) vs Body fat percent which range between 1.2% body fat per allele change to 1.8% body fat per allele change. Need to find SNPs of interest have a Minor Allele Frequency that ranges from 20-40% for the sample size of 250, 300 and 500 subjects and power given to be 80% and 90% based on any alpha value.

snp
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updated by Larry_Parnell Larry_Parnell • written by Samuel David • Samuel David

1 answer

My colleague presented a formula to calculate this for variants in APOA5 in humans for triglyceride concentrations across ethnic groups in Singapore. His paper, which includes that formula, can be found here.

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written by Larry_Parnell Larry_Parnell

what is called effect size of SNPs? is it the regression coefficient?

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written by Samuel David • Samuel David

The effect size is the beta. From "Statistics at the Bench" by M Bremer and R W Doerge (CSH Press): Effect size is the difference between the control and treatment group that you are trying to detect.

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written by Larry_Parnell Larry_Parnell

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