How can I get pLI scores for a list of Human genes?
I have a list of about 40 Genes of unknown significance. From where can I get pLI scores for them? Thanks in advance for your answers!
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Biostar
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sakina302 •
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sakina302 •
1 answer
See answer here: Where to Download ExAC pLI Scores
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what is 'pLI score" ?
https://decipher.sanger.ac.uk/info/loss-intolerance
The Exome Aggregation Consortium (ExAC) has computed a score called pLI, which indicates the probability that a gene is intolerant to a Loss of Function (LoF) mutation. This analysis is based on high-quality exome sequence data for 60,706 individuals of diverse ethnicities.