Can I use the SCENIC package to analyze the transcription factors in the bulk RNAseq data?
The SCENIC package is software for the analysis of transcription factor activity and localized genes in single-cell transcriptome sequencing data, and the R package also scores the transcription factor activity of each cell.
can I use the pack for bulk seq?
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GouthamAtla
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xiaoguang
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xiaoguang
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May be It’s not a good idea. One of the first steps in SCENIC is to build the co-expression modules. Do you have enough samples to build the co-expression modules with enough biological heterogeneity among them ? Also the AUCell doesn’t seem to work for bulk rna-seq data.
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