Branch length and maximum likelihood
1
0
Entering edit mode
4.1 years ago

For phylogenetics, say you have a tree and calculate the maximum likelihood of two sites. If site 1 is less likely than site 2, how would you alter the branch lengths to make site 1 more likely? Would you increase or decrease the branch lengths?

Or, you can answer this question: if you have a higher branch length, is the maximum likelihood going to be bigger?

branch-length phylogenetic-tree • 1.4k views
ADD COMMENT
0
Entering edit mode

What do you mean by "site" and "less likely"?

ADD REPLY
0
Entering edit mode

I mean two sites of two different sequences. By less likely, I mean a smaller posterior probability

ADD REPLY
0
Entering edit mode

Sorry I'm just learning bioinformatics.

ADD REPLY
0
Entering edit mode

Sorry, I still didn't understand your question, consider revising it or adding a figure

ADD REPLY
0
Entering edit mode

Okay so how about would a larger branch length make the maximum likelihood bigger?

ADD REPLY
0
Entering edit mode
4.1 years ago
Mensur Dlakic ★ 27k

Branch length (BL) and posterior probabilities (PPs) are not correlated variables between themselves, or even with regard to maximum likelihood (ML). You can think of the first two as "local" variables that describe distances between tree members (BLs) or how likely a particular branch topology is (PPs). Following that analogy, ML is a "global" variable that describes the relative fitness of the whole tree topology.

What this means is that we can have identical BLs but different PPs of the same branch in two different contexts. It also means that if you add a new member to a tree, the ML with change (it will decrease) even if the overall topology, individual BLs and PPs remain the same. In a nutshell, ML is negatively correlated with the alignments size (# columns * # members). BLs are positively correlated with member distances. PP estimates how likely a given topology is, which in general is not correlated with either BLs or ML.

ADD COMMENT

Login before adding your answer.

Traffic: 2630 users visited in the last hour
Help About
FAQ
Access RSS
API
Stats

Use of this site constitutes acceptance of our User Agreement and Privacy Policy.

Powered by the version 2.3.6