capture-based plasma cnv calling

Question

[lffu_0032]

Hi, Is there any tools can be used to call CNV in capture-based plasma sequencing data? Thanks a lot.

Answer 1

[Kevin Blighe]

You could try DNAcopy (R) or Control-FREEC, or just use a customised method that utilises circular binary segmentation (CBS) and adjusts for sequencing depth across samples / libraries and also GC content.

Kevin