Hierarchical Clustering of Single-Cell Counts
I have a normalized cell-matrix of about 10,000 cells that I would like to run hierarchical clustering on. I've already done a graph-based clustering approach, and this is something as an added analysis.
I've been following this guide (CH 10) https://osca.bioconductor.org/clustering.html#hierarchical-clustering However, I was wondering if there were any better approaches.
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Is there a particular purpose for the clustering? Why isn't the method specified sufficient?