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DEGs analysis with StringTie results?

Hello All, I am working on differential gene expression analysis using the stringTie assembly tools. For count matrix, prepDE generating two files gene_count_matrix and transcript_count_matrix. As per the protocol they have used the gene_count_matix file for the DEGs analysis. Is it possible to do to DEGs with transcript_count matrix, if so what could be the main difference?

stringtie degs deseq2

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