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is it okay to draw PIP interactions using down-regulated genes?,

Hi,

I got RNA seq data from the company. There are more down-regulated genes than up-regulated genes.

I generally thought in the paper that I use a series of upregulated gene to draw a string network (PIP interaction).

So is it okay to draw PIP interactions using down-regulated genes?

Thank you in advance.

rna-seq gene string

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