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DESeq2 results versus by eye comparison in IGV
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14 months ago

Naive question but is it common for the fold change in gene expression for a locus to appear greater by eye in IGV than in the fold change calculated by DESeq2?

For example, the log2FC of geneA is -1.667704322

IGV view of geneA

These tracks are group autoscaled.

Thank you in advance!

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Entering edit mode
18 months ago
swbarnes2 5.7k
United States

IGV likely is not normalized, and DESeq is.

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