Hello everybody,

I am working on region-based variants association testing from sequencing data with related samples. I know that there are several approaches (Burden testing, SKAT, SKAT-O...) -implemented by several tools- to estimate a region-based association p-value. I am aware that kernel association tests assume different effect directions and sizes for the variants within the region, but, I was wondering if there is any tool/method for estimating a region-based association effect size (allowing for related samples and for both continuous and dichotomous traits).

Thanks in advance.