I am working on some VCF files, I was wondering (I could not find this answer searching on the web) if there is a rule or definition to consider hom based on AD. A lot of variants are defined hom if they have very few REF alleles, but in some cases I saw that, as example, a 92,342 (ref, alt) is considered 1/1 (hom), and also some 56,227or 7,31 etc

I imagine it depends on some kind of ratio amongst total read depth and altered depth, but I was wonder which threshold is normally used.

Thanks in advance for any help!