Because it probably means there has been some kind of strand-flip.
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I am using Michigan Imputation Server. I have performed a initial QC and removed monomorphic sites and sites with MAF > 0.5. However, the QC step on the server failed. There is no error message or logfile that I can check.
So I just do not know how to find out what is wrong with my VCF file.
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Why did you remove MAF > .5?