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Partial correlation matrix and gene cluster
Hello Biostar community,
I am using partial correlation methods, i.e. SPACE or GeneNet, to construct gene networks. Can I use the partial correlation matrix for hierarchical clustering so that I can identify the gene clusters? It is common to use the traditional correlation matrix for hierarchical clustering to identify gene clusters. How about the partial correlation matrix?
Regards,
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You can do clustering using partial correlations. The partial correlation between X and Y controlling for the effect of Z is the correlation between the residuals of the linear regressions of X on Z and Y on Z. One way of seeing it is as the cosine of the angle between the projections of X and Y in a plane perpendicular to the direction of Z.
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